Isolating Aquaculture & Hydroponics


I am curious about the way to handle diseases in an Aquaponics System. The point that I am interested in is how to isolate Aquaculture & Hydroponics from each other.

Upon isolation of the Aquaculture side, it is simply a RAS system. So while registering the necessary treatment does water needs to be recycled or feeding needs to be continued ?

Does The Sump must serve the hydroponics or the RAS part of the Aquaponics System or each one needs a sump of their own to manage both the systems properly ?

Best Regards